Tennessee Titans vs. Indianapolis Colts: 6 things to know about Week 6

The Tennessee Titans will try to stop their losing streak when they visit the Indianapolis Colts in Week 6 of the 2026 NFL season. Tennessee fell to 0-5 after suffering a 26-3 home loss to the Houston Texans in Week 5. Meanwhile, Indianapolis dropped to 2-3 following a 34-22 road loss to the Pittsburgh Steelers. The Titans now face a familiar AFC South rival that has consistently given them trouble. Here are six things to know ahead of Sunday's matchup. Indianapolis has dominated this rivalry recently, winning six consecutive games against Tennessee.